Inflammation, neovascularization and intra-plaque hemorrhage are associated with increased reparative collagen content: implication for plaque progression in diabetic atherosclerosis.

@article{Purushothaman2011InflammationNA,
  title={Inflammation, neovascularization and intra-plaque hemorrhage are associated with increased reparative collagen content: implication for plaque progression in diabetic atherosclerosis.},
  author={K. Raman Purushothaman and Meerarani Purushothaman and Paul Muntner and Patrick A. Lento and William N O'Connor and Samin K. Sharma and Valentin Fuster and Pedro Rozas Moreno},
  journal={Vascular medicine},
  year={2011},
  volume={16 2},
  pages={103-8}
}
Sustained inflammation may stimulate a reparative process increasing early reparative type III collagen synthesis, promoting atherosclerotic plaque progression. We evaluated inflammation, neovascularization, intra-plaque hemorrhage (IPH), and collagen deposition in human aortic atherosclerotic plaques from patients with and without diabetes mellitus (DM). Plaques were procured at autopsy from lower thoracic and abdominal aorta from DM (n = 20) and non-DM (n = 22) patients. Inflammation and… CONTINUE READING

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