Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice.

  title={Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice.},
  author={Yanli Song and Laura A. Coleman and Jianru Shi and Hideyuki Beppu and Kaori Sato and Kenneth Walsh and Joseph Loscalzo and Ying-yi Zhang},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={295 2},
Heterozygous bone morphogenetic protein receptor-II-knockout (BMPR2(+/-)) mice have a similar genetic trait like that in some idiopathic pulmonary arterial hypertension patients. To examine the effect of pulmonary endothelial injury in BMPR2(+/-) mice, we challenged the mice with two injections of monocrotaline combined with intratracheal instillation of replication-deficient adenovirus expressing 5-lipoxygenase (MCT+Ad5LO). After the challenge (1 wk), BMPR2(+/-) mice exhibited a doubling of… CONTINUE READING


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