Inflammation, Neurodegenerative Diseases, and Environmental Exposures

@article{Campbell2004InflammationND,
  title={Inflammation, Neurodegenerative Diseases, and Environmental Exposures},
  author={Arezoo Campbell},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1035}
}
  • A. Campbell
  • Published 1 December 2004
  • Biology
  • Annals of the New York Academy of Sciences
Abstract: The etiology of neurodegenerative disorders is multifactorial and consists of an interaction between aging, environmental factors, and genetic predisposition. Neuronal cell loss in specific regions of the central nervous system and the resulting clinical symptoms are used to characterize different neurological syndromes. While the selectivity of neuronal cell death is not clearly understood, it is in part attributed to the physiological role and microenvironment of the impacted cells… 
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References

SHOWING 1-10 OF 116 REFERENCES
Exacerbation of Motor Neuron Disease by Chronic Stimulation of Innate Immunity in a Mouse Model of Amyotrophic Lateral Sclerosis
TLDR
The effects of acute and chronic administration of lipopolysaccharide (LPS) are addressed in a genetic model of neurodegeneration to provide solid evidence that environmental factors and innate immunity can cooperate to influence the course of disease of an inherited neuropathology.
Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation.
TLDR
Deciphering the molecular and cellular mechanisms governing those intricate interactions would significantly advance the understanding of the etiology and pathogenesis of PD and aid the development of therapeutic strategies for the treatment of the disease.
Glucocorticoids Play a Fundamental Role in Protecting the Brain during Innate Immune Response
TLDR
It is shown that activation of this system is not detrimental for the brain but a profound neurodegeneration takes place in animals treated with the glucocorticoid receptor inhibitor Mifepristone (RU486).
Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism
TLDR
This demonstration of how Aβ couples an intracellular signal transduction pathway involving NFκB to a potentially neurotoxic response provides a key mechanistic link between Aβ and the generation of oxidative damage.
Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons
TLDR
This is the first report demonstrating that microglia play a pivotal role in rotenone-induced degeneration of dopaminergic neurons, and should advance the understanding of the mechanism of action for pesticides in the pathogenesis of Parkinson's disease.
Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain
TLDR
Al exposure may not be sufficient to cause abnormal production of the principal component of senile plaques directly but does exacerbate underlying events associated with brain aging and thus could contribute to progression of neurodegeneration.
...
1
2
3
4
5
...