Inflammasomes in health and disease

@article{Strowig2012InflammasomesIH,
  title={Inflammasomes in health and disease},
  author={Till Strowig and Jorge Henao-Mejia and Eran Elinav and Richard A. Flavell},
  journal={Nature},
  year={2012},
  volume={481},
  pages={278-286}
}
Inflammasomes are a group of protein complexes built around several proteins, including NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and damage signals by inflammasomes results in direct activation of caspase-1, which subsequently induces secretion of potent pro-inflammatory cytokines and a form of cell death called pyroptosis. Inflammasome-mediated processes are important during microbial infections and also in regulating both metabolic processes and… 

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