Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota.

@article{Gagliani2014InflammasomesAI,
  title={Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota.},
  author={Nicola Gagliani and Noah W Palm and Marcel R. de Zoete and Richard A Flavell},
  journal={International immunology},
  year={2014},
  volume={26 9},
  pages={
          495-9
        }
}
Inflammasomes are large cytosolic protein complexes that detect infection and stress-associated signals and promote immediate inflammatory responses. In the intestine, activation of the inflammasome leads to an inflammatory response that is important for controlling enteric infections but can also result in pathological tissue damage. Recent studies have suggested that the inflammasome also regulates intestinal homeostasis through its effects on the intestinal microbiota. Notably, many… CONTINUE READING
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