Inflammasomes and autoimmunity.

Abstract

The NOD-like receptor (NLR) family members are cytosolic sensors of microbial components and danger signals. A subset of NLRs control inflammasome assembly that results in caspase-1 activation and, in turn, IL-1β and IL-18 production. Excessive inflammasome activation can cause autoinflammatory disorders, including the hereditary periodic fevers… (More)
DOI: 10.1016/j.molmed.2010.11.001

Topics

  • Presentations referencing similar topics