Inflammasomes: mechanism of assembly, regulation and signalling

  title={Inflammasomes: mechanism of assembly, regulation and signalling},
  author={Petr Bro{\vz} and Vishva M. Dixit},
  journal={Nature Reviews Immunology},
Inflammasomes are multiprotein signalling platforms that control the inflammatory response and coordinate antimicrobial host defences. They are assembled by pattern-recognition receptors following the detection of pathogenic microorganisms and danger signals in the cytosol of host cells, and they activate inflammatory caspases to produce cytokines and to induce pyroptotic cell death. The clinical importance of inflammasomes reaches beyond infectious disease, as dysregulated inflammasome… 

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Inflammasomes and the fine line between defense and disease.

Structures and functions of the inflammasome engine.

Activation and manipulation of inflammasomes and pyroptosis during bacterial infections.

The mechanisms by which inflammasomes sense pathogen invasion and initiate pyroptosis and the effector mechanisms used by pathogens to suppress this pathway and preserve their niche are discussed.

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    Microbiology spectrum
  • 2019
This review discusses how intracellular bacteria are detected by inflammasomes, how the specific sensing mechanism of eachinflammasome receptor restricts the ability of bacteria to evade immune recognition, and how host cell death is used to control bacterial replication in vivo.

Regulation of Inflammasome by Autophagy.

  • T. Liu
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    Advances in experimental medicine and biology
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Recent developments on inflammasome-associated effector functions are reviewed with an emphasis on the emerging roles of gasdermin pores and pyroptosis.



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It is concluded that inflammasomes represent a highly adaptable scaffold ideally suited for detecting and initiating rapid innate responses to diverse and rapidly evolving bacteria.

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In mouse macrophages, signaling by the pattern recognition receptor TLR4 through MyD88 can rapidly and non-transcriptionally prime NLRP3 by stimulating its deubiquitination, which could explain how NL RP3 is activated by diverse danger signals.

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