Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids.

@article{Snodgrass2013InflammasomemediatedSO,
  title={Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids.},
  author={Ryan G. Snodgrass and Shurong Huang and Il-Whan Choi and John C. Rutledge and Daniel H. Hwang},
  journal={Journal of immunology},
  year={2013},
  volume={191 8},
  pages={4337-47}
}
Many studies have shown that TLR4- and TLR2-deficient mice are protected from high-fat diet-induced inflammation and insulin resistance, suggesting that saturated fatty acids derived from the high-fat diet activate TLR-mediated proinflammatory signaling pathways and induce insulin resistance. However, evidence that palmitic acid, the major dietary saturated fatty acid, can directly activate TLR has not been demonstrated. In this article, we present multiple lines of evidence showing that… CONTINUE READING
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