Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

@inproceedings{HenaoMejia2012InflammasomemediatedDR,
  title={Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity},
  author={Jorge Henao-Mejia and Eran Elinav and Cheng-Cheng Jin and Liming Hao and Wajahat Z Mehal and Till Strowig and Christoph A. Thaiss and Andrew L Kau and Stephanie C Eisenbarth and Michael J Jurczak and Jo{\~a}o-Paulo G. Camporez and Gerald I Shulman and Jeffrey I. Gordon and Hal M. Hoffman and Richard A Flavell},
  booktitle={Nature},
  year={2012}
}
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and the leading cause of chronic liver disease in the Western world. Twenty per cent of NAFLD individuals develop chronic hepatic inflammation (non-alcoholic steatohepatitis, NASH) associated with cirrhosis, portal hypertension and hepatocellular carcinoma, yet the causes of progression from NAFLD to NASH remain obscure. Here, we show that the NLRP6 and NLRP3 inflammasomes and the effector protein IL-18… CONTINUE READING
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