Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

@article{Brydges2009InflammasomemediatedDA,
  title={Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.},
  author={Susannah D. Brydges and James Mueller and Matthew D. McGeough and Carla A. Pe{\~n}a and Amirhossein Misaghi and Chhavi Gandhi and Chris D Putnam and David L. Boyle and Gary S. Firestein and Anthony Adam Horner and Pejman Soroosh and Wendy T Watford and John J O'Shea and Daniel L. Kastner and Hal M. Hoffman},
  journal={Immunity},
  year={2009},
  volume={30 6},
  pages={875-87}
}
NLRP3 nucleates the inflammasome, a protein complex responsible for cleavage of prointerleukin-1beta (IL-1beta) to its active form. Mutations in the NLRP3 gene cause the autoinflammatory disease spectrum cryopyrin-associated periodic syndromes (CAPS). The central role of IL-1beta in CAPS is supported by the response to IL-1-targeted therapy. We developed two Nlrp3 mutant knockin mouse strains to model CAPS to examine the role of other inflammatory mediators and adaptive immune responses in an… CONTINUE READING