Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases.

@article{Burm2015InflammasomeinducedIS,
  title={Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases.},
  author={Saskia Maria Burm and Ella Alwine Zuiderwijk-Sick and Anke E J 't Jong and C{\'e}line van der Putten and Jennifer Veth and Ivanela I. Kondova and Jeffrey J Bajramovic},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 2},
  pages={678-87}
}
Inflammasomes are multiprotein complexes that link pathogen recognition and cellular stress to the processing of the proinflammatory cytokine interleukin-1β (IL-1β). Whereas inflammasome-mediated activation is heavily studied in hematopoietic macrophages and dendritic cells, much less is known about microglia, resident tissue macrophages of the brain that originate from a distinct progenitor. To directly compare inflammasome-mediated activation in different types of macrophages, we isolated… CONTINUE READING
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