Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59.

@article{Ellebedy2011InflammasomeindependentRO,
  title={Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59.},
  author={Ali H. Ellebedy and Christopher R. Lupfer and Hazem E. Ghoneim and Jennifer L Debeauchamp and Thirumala-Devi Kanneganti and Richard R. J. Webby},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 7},
  pages={2927-32}
}
Clinical studies have indicated that subvirion inactivated vaccines against avian influenza viruses, particularly H5N1, are poorly immunogenic in humans. As a consequence, the use of adjuvants has been championed for the efficient vaccination of a naïve population against avian influenza. Aluminum salts (alum) and the oil-in-water emulsion MF59 are safe and effective adjuvants that are being used with influenza vaccines, but the mechanism underlying their stimulation of the immune system… CONTINUE READING