Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis.

@article{Kumar2013InflammasomeAP,
  title={Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis.},
  author={M. M. Swathanthira Kumar and Kelsey Roe and Beverly Orillo and Daniel A Muruve and Vivek R Nerurkar and Michael T. Gale and Saguna Verma},
  journal={Journal of virology},
  year={2013},
  volume={87 7},
  pages={
          3655-67
        }
}
West Nile virus (WNV) is a neurotropic flavivirus that has emerged globally as a significant cause of viral encephalitis in humans. The WNV-induced innate immune response, including production of antiviral cytokines, is critical for controlling virus infection. The adaptor protein ASC mediates a critical step in innate immune signaling by bridging the interaction between the pathogen recognition receptors and caspase 1 in inflammasome complexes, but its role in WNV immunopathogenesis is not… CONTINUE READING

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