Inflammasome activation via intracellular NLRs triggered by bacterial infection.

@article{Koizumi2012InflammasomeAV,
  title={Inflammasome activation via intracellular NLRs triggered by bacterial infection.},
  author={Yukiko Koizumi and Claudia Toma and Naomi Higa and Toshitsugu Nohara and Noboru Nakasone and Toshihiko Suzuki},
  journal={Cellular microbiology},
  year={2012},
  volume={14 2},
  pages={
          149-54
        }
}
Members of the nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins assemble into a multiprotein platform, known as the inflammasome, to induce caspase-1 activation followed by the subsequent secretion of IL-1β and IL-18. In this review, we focus on the role of NLRs in inflammasome activation as part of the host defence against bacterial pathogens. One of activators of the NLRC4 inflammasome is bacterial flagellin secreted through type III or IV secretion systems, which… CONTINUE READING
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