Inflammasome activation of IL-1 family mediators in response to cutaneous photodamage.

@article{Nasti2012InflammasomeAO,
  title={Inflammasome activation of IL-1 family mediators in response to cutaneous photodamage.},
  author={Tahseen H Nasti and Laura Timares},
  journal={Photochemistry and photobiology},
  year={2012},
  volume={88 5},
  pages={
          1111-25
        }
}
Although keratinocytes are relatively resistant to ultraviolet radiation (UVR) induced damage, repeated UVR exposure result in accumulated DNA mutations that can lead to epidermal malignancies. Keratinocytes play a central role in elaborating innate responses that lead to inflammation and influence the generation of adaptive immune responses in skin. Apart from the minor cellular constituents of the epidermis, specifically Langerhans cells and melanocytes, keratinocytes are the major source of… CONTINUE READING
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