Inflammasome activation in bovine monocytes by extracellular ATP does not require the purinergic receptor P2X7.

@article{Hussen2012InflammasomeAI,
  title={Inflammasome activation in bovine monocytes by extracellular ATP does not require the purinergic receptor P2X7.},
  author={Jamal Hussen and Anna D{\"u}vel and Mirja Koy and Hans-Joachim Schuberth},
  journal={Developmental and comparative immunology},
  year={2012},
  volume={38 2},
  pages={312-20}
}
Extracellular adenosine triphosphate (ATP) is a second signal for the assembly of the NLR family, pyrin domain-containing 3 (NLRP3) inflammasome, which form a framework to activate caspase 1, leading to the processing and secretion of the pro-inflammatory cytokine interleukin-1β (IL-1β). The aim of the present study was to investigate the role of the ATP… CONTINUE READING