Inflammasome-Mediated Production of IL-1β Is Required for Neutrophil Recruitment against Staphylococcus aureus In Vivo1

@article{Miller2007InflammasomeMediatedPO,
  title={Inflammasome-Mediated Production of IL-1$\beta$ Is Required for Neutrophil Recruitment against Staphylococcus aureus In Vivo1},
  author={Lloyd S. Miller and Eric M Pietras and Lawrence H. Uricchio and Kathleen Hirano and Shyam Rao and Heping Lin and Ryan M O'Connell and Yoichiro Iwakura and Ambrose L Cheung and Genhong Cheng and Robert L. Modlin},
  journal={The Journal of Immunology},
  year={2007},
  volume={179},
  pages={6933 - 6942}
}
IL-1R activation is required for neutrophil recruitment in an effective innate immune response against Staphylococcus aureus infection. In this study, we investigated the mechanism of IL-1R activation in vivo in a model of S. aureus infection. In response to a S. aureus cutaneous challenge, mice deficient in IL-1β, IL-1α/IL-1β, but not IL-1α, developed larger lesions with higher bacterial counts and had decreased neutrophil recruitment compared with wild-type mice. Neutrophil recruitment and… Expand
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