Inflammasome-IL-1-Th17 response in allergic lung inflammation.

  title={Inflammasome-IL-1-Th17 response in allergic lung inflammation.},
  author={Anne-Gaelle Besnard and Dieudonn{\'e}e Togb{\'e} and Isabelle Couillin and Zoming Tan and Song Guo Zheng and François Erard and Marc Le Bert and Val{\'e}rie F J Quesniaux and Bernhard Ryffel},
  journal={Journal of molecular cell biology},
  volume={4 1},
Allergic asthma has increased dramatically in prevalence and severity over the last three decades. Both clinical and experimental data support an important role of Th2 cell response in the allergic response. Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid, activating the NLRP3 inflammasome complex and cleaving pro-IL-1β to mature IL-1β through caspase-1. The production of pro-IL-1β requires a toll-like receptor… CONTINUE READING