Inflammasome-Dependent Induction of Adaptive NK Cell Memory.

  title={Inflammasome-Dependent Induction of Adaptive NK Cell Memory.},
  author={Jasper G. van den Boorn and Christopher Jakobs and Christian Hagen and Marcel Renn and Rosalie M. Luiten and Cornelis J M Melief and Thomas T{\"u}ting and Natalio Garbi and Gunther Hartmann and V. Hornung},
  volume={44 6},
Monobenzone is a pro-hapten that is exclusively metabolized by melanocytes, thereby haptenizing melanocyte-specific antigens, which results in cytotoxic autoimmunity specifically against pigmented cells. Studying monobenzone in a setting of contact hypersensitivity (CHS), we observed that monobenzone induced a long-lasting, melanocyte-specific immune response that was dependent on NK cells, yet fully intact in the absence of T- and B cells. Consistent with the concept of "memory NK cells… CONTINUE READING
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