Inflammasome Activation in Chronic Glomerular Diseases.

  title={Inflammasome Activation in Chronic Glomerular Diseases.},
  author={Sabena Michelle Conley and Justine M. Abais and Krishna Murthy Boini and P L Li},
  journal={Current drug targets},
  volume={18 9},
BACKGROUND The intracellular multiprotein complex termed the inflammasome functions as a platform of pro-inflammatory cytokine production such as IL-1β and IL-18. Under certain conditions, however, the inflammasome produces non-canonical effects such as induction of cell death, pyroptosis and cell metabolism alterations. OBJECTIVE In mammalian cells, several types of inflammasomes were identified, but the most widely studied one is the inflammasome containing NOD-like receptor with pyrin… CONTINUE READING