Inflammasome Activation Contributes to Interleukin-23 Production in Response to Clostridium difficile

Abstract

UNLABELLED Clostridium difficile is the most common hospital-acquired pathogen, causing antibiotic-associated diarrhea in over 250,000 patients annually in the United States. Disease is primarily mediated by toxins A and B, which induce potent proinflammatory signaling in host cells and can activate an ASC-containing inflammasome. Recent findings suggest… (More)
DOI: 10.1128/mBio.02386-14

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