Inflammasome/IL-1β Responses to Streptococcal Pathogens

  title={Inflammasome/IL-1β Responses to Streptococcal Pathogens},
  author={Christopher N LaRock and Victor Nizet},
  booktitle={Front. Immunol.},
Inflammation mediated by the inflammasome and the cytokine IL-1β are some of the earliest and most important alarms to infection. These pathways are responsive to the virulence factors that pathogens use to subvert immune processes, and thus are typically activated only by microbes with potential to cause severe disease. Among the most serious human infections are those caused by the pathogenic streptococci, in part because these species numerous strategies for immune evasion. Since the… CONTINUE READING
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