Inflamm-aging. An evolutionary perspective on immunosenescence.

@article{Franceschi2000InflammagingAE,
  title={Inflamm-aging. An evolutionary perspective on immunosenescence.},
  author={Claudio Franceschi and Massimiliano Bonaf{\'e} and Silvana Valensin and Fabiola Olivieri and Marco De Luca and Enzo Ottaviani and Giovanna de Benedictis},
  journal={Annals of the New York Academy of Sciences},
  year={2000},
  volume={908},
  pages={244-54}
}
In this paper we extend the "network theory of aging," and we argue that a global reduction in the capacity to cope with a variety of stressors and a concomitant progressive increase in proinflammatory status are major characteristics of the aging process. This phenomenon, which we will refer to as "inflamm-aging," is provoked by a continuous antigenic load… CONTINUE READING