Inflamed macrophage microvesicles induce insulin resistance in human adipocytes

  title={Inflamed macrophage microvesicles induce insulin resistance in human adipocytes},
  author={Yaqin Zhang and Li Shi and Hongliang Mei and Jiexin Zhang and Yunxia Zhu and Xiao Han and Dalong Zhu},
  booktitle={Nutrition & metabolism},
BACKGROUND Cytokines secreted by adipose tissue macrophages (ATMs) significantly alter adipocyte function, inducing inflammatory responses and decreasing insulin sensitivity. However, little relevant information is available regarding the role of microvesicles (MVs) derived from ATMs in macrophage-adipocyte crosstalk. METHODS MVs were generated by stimulation of M1 or M2 phenotype THP-1 macrophages and incubated with human primary mature adipocytes and differentiated adipocytes. Subsequently… CONTINUE READING
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