Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression.

@article{Tazawa2003InfiltrationON,
  title={Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression.},
  author={Hiroshi Tazawa and Futoshi Okada and Tokushige Kobayashi and Mitsuhiro Tada and Yukiko Mori and Yoshie Une and Fujiro Sendo and Masanobu Kobayashi and Masuo Hosokawa},
  journal={The American journal of pathology},
  year={2003},
  volume={163 6},
  pages={
          2221-32
        }
}
QR-32 tumor cells, a clone derived from a murine fibrosarcoma, are poorly tumorigenic and nonmetastatic when injected into syngeneic C57BL/6 mice. However, they are converted to highly malignant ones once they have grown in vivo after being co-implanted in a subcutaneous site with a foreign body, a gelatin sponge. Early phase of inflammation induced by the gelatin sponge participates in the conversion and histological analysis shows predominant infiltration of neutrophils. The objective of this… CONTINUE READING

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