Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth.

@article{Nakao2005InfiltrationOC,
  title={Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth.},
  author={Shintaro Nakao and Takashi Kuwano and Chikako Tsutsumi-Miyahara and Shu-ichi Ueda and Yusuke Norman Kimura and Shinjiro Hamano and Koh-hei Sonoda and Yasuo Saijo and Toshihiro Nukiwa and Robert M. Strieter and T Ishibashi and Michihiko Kuwano and Mayumi Ono},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 11},
  pages={2979-91}
}
Inflammatory angiogenesis is a critical process in tumor progression and other diseases. The inflammatory cytokine IL-1beta promotes angiogenesis, tumor growth, and metastasis, but its mechanisms remain unclear. We examined the association between IL-1beta-induced angiogenesis and cell inflammation. IL-1beta induced neovascularization in the mouse cornea at rates comparable to those of VEGF. Neutrophil infiltration occurred on day 2. Macrophage infiltration occurred on days 4 and 6. The anti-Gr… CONTINUE READING
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