Infiltrating leukocyte populations and T-lymphocyte subsets in head and neck squamous cell carcinomas from patients receiving perilymphatic injections of recombinant interleukin 2. A pathologic and immunophenotypic study.

@article{Valente1990InfiltratingLP,
  title={Infiltrating leukocyte populations and T-lymphocyte subsets in head and neck squamous cell carcinomas from patients receiving perilymphatic injections of recombinant interleukin 2. A pathologic and immunophenotypic study.},
  author={Guido Valente and Antonella De Stefani and Cristina Jemma and Mirella Giovarelli and Massimo Geuna and Giorgio Cortesina and Guido Forni and Giorgio Palestro},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  year={1990},
  volume={3 6},
  pages={702-8}
}
Nine patients with squamous cell carcinoma of the oral cavity and oropharynx underwent preoperative perilymphatic administration of recombinant interleukin 2 (rIL-2). A more marked eosinophil and lymphocyte infiltration and more extensive edema than in 13 untreated cases were observed in surgical specimens. Necrosis was present in five of nine cases, but involved no more than 10% of the neoplastic tissue; in three of nine cases, characteristic necrotic changes with intense eosinophil… CONTINUE READING