Infertility in females with cystic fibrosis is multifactorial: evidence from mouse models.

@article{Hodges2008InfertilityIF,
  title={Infertility in females with cystic fibrosis is multifactorial: evidence from mouse models.},
  author={Craig A Hodges and Mark R. Palmert and Mitchell L. Drumm},
  journal={Endocrinology},
  year={2008},
  volume={149 6},
  pages={2790-7}
}
Infertility is commonly associated with cystic fibrosis (CF). Although infertility in men with CF has been thoroughly investigated, the infertility observed in women with CF has not been well studied. To investigate female infertility associated with CF, we used two independently derived mouse models of CF. Both of these models displayed decreased fertility characterized by a reduction in litter number and litter size. Our findings suggest that much of the reduced fertility in these mice… CONTINUE READING