Infertility in adult hypodactyly mice is associated with hypoplasia of distal reproductive structures.

@article{Post1999InfertilityIA,
  title={Infertility in adult hypodactyly mice is associated with hypoplasia of distal reproductive structures.},
  author={Laura C. Post and John W. Innis},
  journal={Biology of reproduction},
  year={1999},
  volume={61 6},
  pages={
          1402-8
        }
}
Hypodactyly (Hoxa13(Hd)) mice have a 50-base-pair deletion in Hoxa13, and rare surviving homozygotes of both sexes are infertile. Heterozygous mutant mice are fertile; however, Hoxa13(Hd/+) females exhibit an anterior transformation of cervical tissue to a uterine stromal phenotype that is accentuated in the homozygote and occasionally includes uterine-specific glands in the transformed cervical region. The columnar-to-squamosal epithelial transition that characterizes mature cervical-vaginal… CONTINUE READING

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