Infertility and testicular atrophy in the antiestrogen-treated adult male rat.

@article{Oliveira2001InfertilityAT,
  title={Infertility and testicular atrophy in the antiestrogen-treated adult male rat.},
  author={Cleida A. Oliveira and Kay Carnes and Luiz Renato de França and Rex Allen Hess},
  journal={Biology of reproduction},
  year={2001},
  volume={65 3},
  pages={913-20}
}
The estrogen receptor-alpha (ERalpha) knockout mouse (alphaERKO) lacks ERalpha throughout development; therefore, an adult model for the study of estrogen effects in male mice was recently developed using the antiestrogen ICI 182,780. However, differences between species have been noted during immunostaining for ERalpha in the male tract as well as in response to treatments with antiestrogens. Therefore, we developed the antiestrogen model in the adult male rat to test, in another species, the… CONTINUE READING

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