Infertility and Reproductive Function in Patients with Congenital Adrenal Hyperplasia: Pathophysiology, Advances in Management, and Recent Outcomes.

@article{Lekarev2015InfertilityAR,
  title={Infertility and Reproductive Function in Patients with Congenital Adrenal Hyperplasia: Pathophysiology, Advances in Management, and Recent Outcomes.},
  author={Oksana Lekarev and Karen Lin-Su and Maria G. Vogiatzi},
  journal={Endocrinology and metabolism clinics of North America},
  year={2015},
  volume={44 4},
  pages={705-22}
}
Individuals with congenital adrenal hyperplasia have reduced fertility. However, reproductive outcomes have improved over the years. This review provides an update on the multiple pathologic processes that contribute to reduced fertility in both sexes, from alterations of the hypothalamic-pituitary-gonadal axis to the direct effect on gonadal function by elevated circulating adrenal androgens. In addition, elevated serum progesterone concentrations may hinder ovulation and embryo implantation… CONTINUE READING

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