Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies.

@article{Ness2002InfertilityFD,
  title={Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies.},
  author={R. Ness and D. Cramer and M. Goodman and S. Kjaer and K. Mallin and B. Mosgaard and D. Purdie and H. Risch and R. Vergona and A. Wu},
  journal={American journal of epidemiology},
  year={2002},
  volume={155 3},
  pages={
          217-24
        }
}
Controversy surrounds the relations among infertility, fertility drug use, and the risk of ovarian cancer. The authors pooled interview data on infertility and fertility drug use from eight case-control studies conducted between 1989 and 1999 in the United States, Denmark, Canada, and Australia. Odds ratios and 95% confidence intervals were calculated, adjusting for age, race, family history of ovarian cancer, duration of oral contraception use, tubal ligation, gravidity, education, and site… Expand
A case-control study of ovarian cancer in relation to infertility and the use of ovulation-inducing drugs.
TLDR
The hypothesis that a subset of nulliparous women who experience infertility may be at increased risk of ovarian cancer is supported, and the reasons for this increase in risk remain unclear. Expand
Use of Fertility Drugs and Risk of Ovarian Cancer: Results from a U.S.-Based Case–Control Study
TLDR
Fertility drug use does not significantly contribute to overall risk of ovarian cancer when adjusting for known confounding factors, and women who despite infertility evaluation and fertility drug use remain nulligravid, may have an elevated risk for ovarian cancer. Expand
Fertility drug use and the risk of ovarian tumors in infertile women: a case-control study.
TLDR
Infertile women who used fertility drugs were not at increased risk of developing ovarian tumors compared with infertiles women who did not use fertility drugs, and the findings were similar when stratified by gravidity and when analyzed separately for borderline versus invasive tumors. Expand
Ovulation-inducing drugs and ovarian cancer risk: results from an extended follow-up of a large United States infertility cohort.
TLDR
The overall results were reassuring and consistent with other studies and given the large and increasing number of women treated with ovulation-inducing drugs, the increased risk of ovarian cancer among the subset of women who remained nulligravid should be further monitored. Expand
In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk.
TLDR
There is no evidence of an increased risk of ovarian cancer following IVF in women who give birth; nulliparous women have a marked increase in risk. Expand
Ovarian epithelial neoplasia after hormonal infertility treatment: long-term follow-up of a historical cohort in Sweden.
TLDR
Findings of increased risk of ovarian cancer after gonadotropins and of borderline tumors after clomiphene treatment need to be interpreted with caution. Expand
Ovarian Cancer Risk After the Use of Ovulation-Stimulating Drugs
TLDR
The results of this study generally were reassuring in not confirming a strong link between ovulation-stimulating drugs and ovarian cancer, however, support the need for continued monitoring of long-term risks. Expand
Cancer morbidity in a cohort of 9175 Finnish women treated for infertility.
TLDR
General cancer risk or risk of hormonal-related cancers in women was not increased by IVF, and differences in certain cancers suggest a healthy patient effect or may be partly caused by residual socio-economic differences. Expand
Long-term Relationship of Ovulation-Stimulating Drugs to Breast Cancer Risk
TLDR
Although the increased breast cancer risk among nulligravid women associated with gonadotropins most likely reflects an effect of underlying causes of infertility, reasons for the elevated risk associated with multiple clomiphene cycles are less clear. Expand
Do the Fertility Drugs Increase the Risk of Cancer? A Review Study
TLDR
The results of this study did not show that fertility medications increase the risk of cancer among users, but the relationship between infertility treatment and cancer incidence remains an open question. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 39 REFERENCES
Infertility, fertility drugs, and invasive ovarian cancer: a case-control study.
TLDR
Nulliparous women had an increased risk of ovarian cancer compared with parous women, and infertility without medical treatment among these women increased the risk further, while treatment with fertility drugs did not increase the ovarian cancer risk among nontreated infertile women. Expand
Infertility and risk of fatal ovarian cancer in a prospective cohort of US women
TLDR
It is suggested that infertility itself, without concomitant exposure to fertility drugs, may increase risk of fatal ovarian cancer among nulligravid women. Expand
Parity, contraception, infertility, and the risk of epithelial ovarian cancer.
TLDR
It was found that childbearing and use of oral contraceptives were associated with significant decreasing trends in risk of ovarian cancer; the respective odds ratios were 0.78 for each full-term pregnancy and 0.92 for each year of use. Expand
Fertility drugs and the risk of breast and ovarian cancers: results of a long-term follow-up study.
TLDR
An association between the use of fertility drugs and an increased risk of breast and ovarian cancers has not been confirmed. Expand
Fertility drugs and risk of epithelial ovarian cancer in Italy.
TLDR
It is indicated that a role of ovarian stimulation in the aetiology of epithelial ovarian cancer is not established, although it is worth investigating. Expand
Pelvic inflammatory disease and the risk of epithelial ovarian cancer.
  • H. Risch, G. Howe
  • Medicine
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1995
TLDR
It was found that cases were more likely than controls to report having had one or more episodes of PID; adjusted for age, parity, duration of oral contraceptive use, and other factors the odds ratio was 1.53; higher risk was present for women with recurrent PID. Expand
Ovarian tumors in a cohort of infertile women.
TLDR
Prolonged use of clomiphene may increase the risk of a borderline or invasive ovarian tumor in women evaluated for infertility between 1974 and 1985. Expand
Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. II. Invasive epithelial ovarian cancers in white women. Collaborative Ovarian Cancer Group.
TLDR
Pregnancy, breast feeding, and oral contraceptive use induce biological changes that protect against ovarian malignancy, that, at most, a small fraction of the excess ovarian cancer risk among nulliparous women is due to infertility, and that any increased risk associated with infertility may be due to the use of fertility drugs. Expand
Cancer risk after evaluation for infertility.
TLDR
A retrospective cohort study among 2,335 women evaluated for infertility at the Mayo Clinic between 1935 and 1964 suggests a possible involvement of a progesterone deficiency in the etiology of other cancers, particularly thyroid cancer and melanoma. Expand
An epidemiologic case-control study of ovarian cancer and reproductive factors.
TLDR
The contraceptive and reproductive patterns observed in this study suggest that infertility plays an important role in determining the relationship between reduced parity and gravidity and increased ovarian cancer risk. Expand
...
1
2
3
4
...