Inferring the paths of somatic evolution in cancer

@article{Misra2014InferringTP,
  title={Inferring the paths of somatic evolution in cancer},
  author={Navodit Misra and Ewa Szczurek and Martin Vingron},
  journal={Bioinformatics},
  year={2014},
  volume={30 17},
  pages={
          2456-63
        }
}
  • Navodit Misra, Ewa Szczurek, Martin Vingron
  • Published in Bioinform. 2014
  • Computer Science, Medicine, Biology
  • MOTIVATION Cancer cell genomes acquire several genetic alterations during somatic evolution from a normal cell type. The relative order in which these mutations accumulate and contribute to cell fitness is affected by epistatic interactions. Inferring their evolutionary history is challenging because of the large number of mutations acquired by cancer cells as well as the presence of unknown epistatic interactions. RESULTS We developed Bayesian Mutation Landscape (BML), a probabilistic… CONTINUE READING

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