Inferring the metabolism of human orphan metabolites from their metabolic network context affirms human gluconokinase activity.

  title={Inferring the metabolism of human orphan metabolites from their metabolic network context affirms human gluconokinase activity.},
  author={{\'O}ttar Rolfsson and Giuseppe La Paglia and Manuela Magn{\'u}sd{\'o}ttir and Bernhard O. Palsson and Ines Thiele},
  journal={The Biochemical journal},
  volume={449 2},
Metabolic network reconstructions define metabolic information within a target organism and can therefore be used to address incomplete metabolic information. In the present study we used a computational approach to identify human metabolites whose metabolism is incomplete on the basis of their detection in humans but exclusion from the human metabolic network reconstruction RECON 1. Candidate solutions, composed of metabolic reactions capable of explaining the metabolism of these compounds… 

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