Inferring the location and effect of tumor suppressor genes by instability-selection modeling of allelic-loss data.

@article{Newton2000InferringTL,
  title={Inferring the location and effect of tumor suppressor genes by instability-selection modeling of allelic-loss data.},
  author={Michael A. Newton and Yueh-Lun Lee},
  journal={Biometrics},
  year={2000},
  volume={56 4},
  pages={1088-97}
}
Cancerous tumor growth creates cells with abnormal DNA. Allelic-loss experiments identify genomic deletions in cancer cells, but sources of variation and intrinsic dependencies complicate inference about the location and effect of suppressor genes; such genes are the target of these experiments and are thought to be involved in tumor development. We… CONTINUE READING