Inferring the Mutational History of a Tumor Using Multi-state Perfect Phylogeny Mixtures.

Abstract

Phylogenetic techniques are increasingly applied to infer the somatic mutational history of a tumor from DNA sequencing data. However, standard phylogenetic tree reconstruction techniques do not account for the fact that bulk sequencing data measures mutations in a population of cells. We formulate and solve the multi-state perfect phylogeny mixture… (More)
DOI: 10.1016/j.cels.2016.07.004

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@article{ElKebir2016InferringTM, title={Inferring the Mutational History of a Tumor Using Multi-state Perfect Phylogeny Mixtures.}, author={Mohammed El-Kebir and Gryte Satas and Layla Oesper and Benjamin J. Raphael}, journal={Cell systems}, year={2016}, volume={3 1}, pages={43-53} }