Inferring the Clonal Structure of Viral Populations from Time Series Sequencing

@inproceedings{Chedom2015InferringTC,
  title={Inferring the Clonal Structure of Viral Populations from Time Series Sequencing},
  author={Donatien F. Chedom and Pablo R. Murcia and Chris D. Greenman},
  booktitle={PLoS Computational Biology},
  year={2015}
}
RNA virus populations will undergo processes of mutation and selection resulting in a mixed population of viral particles. High throughput sequencing of a viral population subsequently contains a mixed signal of the underlying clones. We would like to identify the underlying evolutionary structures. We utilize two sources of information to attempt this… CONTINUE READING