• Corpus ID: 252531222

Inferring subsystem efficiencies in bipartite molecular machines

@inproceedings{Leighton2022InferringSE,
  title={Inferring subsystem efficiencies in bipartite molecular machines},
  author={Matthew P. Leighton and David A. Sivak},
  year={2022}
}

• Matthew P. Leighton, David A. Sivak
• Published 24 September 2022
• Biology

Molecular machines composed of coupled subsystems transduce free energy between different external reservoirs, in the process internally transducing energy and information. While subsystem efficiencies of these molecular machines have been measured in isolation, less is known about how they behave in their natural setting when coupled together and acting in concert. Here we derive upper and lower bounds on the subsystem efficiencies of a bipartite molecular machine. We demon-strate their utility by estimating the efficiencies of the F o and F 1 subunits of ATP synthase and that of kinesin pulling a diffusive cargo.