Inferring subnetworks from perturbed expression profiles

@article{Peer2001InferringSF,
  title={Inferring subnetworks from perturbed expression profiles},
  author={Dana Pe'er and Aviv Regev and Gal Elidan and Nir Friedman},
  journal={Bioinformatics},
  year={2001},
  volume={17 Suppl 1},
  pages={S215-24}
}
Genome-wide expression profiles of genetic mutants provide a wide variety of measurements of cellular responses to perturbations. Typical analysis of such data identifies genes affected by perturbation and uses clustering to group genes of similar function. In this paper we discover a finer structure of interactions between genes, such as causality, mediation, activation, and inhibition by using a Bayesian network framework. We extend this framework to correctly handle perturbations, and to… CONTINUE READING
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