Inferring relevant control mechanisms for interleukin-12 signaling in naïve CD4+ T cells.

Abstract

Interleukin-12 (IL-12) is a key cytokine involved in shaping the cell-mediated immunity to intracellular pathogens. IL-12 initiates a cellular response through the IL-12 signaling pathway, a member of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) family of signaling networks. The JAK/STAT pathway includes several regulatory… (More)
DOI: 10.1038/icb.2010.69

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