Inferring natural selection on fine-scale chromatin organization in yeast.

@article{Babbitt2008InferringNS,
  title={Inferring natural selection on fine-scale chromatin organization in yeast.},
  author={Gregory Babbitt and Yuseob Kim},
  journal={Molecular biology and evolution},
  year={2008},
  volume={25 8},
  pages={1714-27}
}
Despite its potential role in the evolution of complex phenotypes, the detection of negative (purifying) and positive selection on noncoding regulatory sequence has been elusive because of the inherent difficulty in predicting the functional consequences of mutations on noncoding sequence. Because the functioning of regulatory sequence depends upon both chromatin configuration and cis-regulatory factor binding, we investigate the idea that the functional conservation of regulatory regions… CONTINUE READING

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