Inferring models of multiscale copy number evolution for single-tumor phylogenetics

  title={Inferring models of multiscale copy number evolution for single-tumor phylogenetics},
  author={Salim Akhter Chowdhury and E. Michael Gertz and Darawalee Wangsa and Kerstin Heselmeyer-Haddad and Thomas Ried and Alejandro A. Sch{\"a}ffer and Russell Schwartz},
MOTIVATION Phylogenetic algorithms have begun to see widespread use in cancer research to reconstruct processes of evolution in tumor progression. Developing reliable phylogenies for tumor data requires quantitative models of cancer evolution that include the unusual genetic mechanisms by which tumors evolve, such as chromosome abnormalities, and allow for heterogeneity between tumor types and individual patients. Previous work on inferring phylogenies of single tumors by copy number evolution… CONTINUE READING


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Phylogenetic analysis of multiprobe fluorescence in situ hybridization data from tumor cell populations

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