Inferring functional information from domain co-evolution

  title={Inferring functional information from domain co-evolution},
  author={Yohan Kim and Mehmet Koyut{\"u}rk and Umut Topkara and Ananth Grama and Shankar Subramaniam},
  volume={22 1},
MOTIVATION Co-evolution is a powerful mechanism for understanding protein function. Prior work in this area has shown that co-evolving proteins are more likely to share the same function than those that do not because of functional constraints. Many of the efforts founded on this observation, however, are at the level of entire sequences, implicitly assuming that the complete protein sequence follows a single evolutionary trajectory. Since it is well known that a domain can exist in various… CONTINUE READING
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