Inferring alterations in cell-to-cell communication in HER2+ breast cancer using secretome profiling of three cell models.

@article{Klinke2014InferringAI,
  title={Inferring alterations in cell-to-cell communication in HER2+ breast cancer using secretome profiling of three cell models.},
  author={David J. Klinke and Yogesh M. Kulkarni and Yueting Wu and Christina N Byrne-Hoffman},
  journal={Biotechnology and bioengineering},
  year={2014},
  volume={111 9},
  pages={1853-63}
}
Challenges in demonstrating durable clinical responses to molecular-targeted therapies have sparked a re-emergence in viewing cancer as an evolutionary process. In somatic evolution, cellular variants are introduced through a random process of somatic mutation and are selected for improved fitness through a competition for survival. In contrast to Darwinian evolution, cellular variants that are retained may directly alter the fitness competition. If cell-to-cell communication is important for… CONTINUE READING