Inferring Reasons for the Failure of Staphylococcus aureus Vaccines in Clinical Trials

@inproceedings{Bagnoli2012InferringRF,
  title={Inferring Reasons for the Failure of Staphylococcus aureus Vaccines in Clinical Trials},
  author={Fabio Bagnoli and Sylvie Bertholet and Guido Grandi},
  booktitle={Front. Cell. Inf. Microbio.},
  year={2012}
}
Multidrug resistant Staphylococcus aureus strains are emerging and current antibiotics are not efficacious against such strains. Therefore, there is an urgent need to develop vaccines to target this pathogen. However, both active and passive immunization strategies have thus far failed to show efficacy in humans. There are several potential reasons behind the disappointing results of clinical trials, however, we believe that just a few of them, which are common to all the trials, determined… CONTINUE READING

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