Inferring HIV Escape Rates from Multi-Locus Genotype Data

  title={Inferring HIV Escape Rates from Multi-Locus Genotype Data},
  author={Taylor A. Kessinger and Alan S. Perelson and Richard A. Neher},
  booktitle={Front. Immunol.},
Cytotoxic T-lymphocytes (CTLs) recognize viral protein fragments displayed by major histocompatibility complex molecules on the surface of virally infected cells and generate an anti-viral response that can kill the infected cells. Virus variants whose protein fragments are not efficiently presented on infected cells or whose fragments are presented but not recognized by CTLs therefore have a competitive advantage and spread rapidly through the population. We present a method that allows a more… CONTINUE READING
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