Inferring Growth Control Mechanisms in Growing Multi-cellular Spheroids of NSCLC Cells from Spatial-Temporal Image Data

@article{Jagiella2016InferringGC,
  title={Inferring Growth Control Mechanisms in Growing Multi-cellular Spheroids of NSCLC Cells from Spatial-Temporal Image Data},
  author={Nick Jagiella and Benedikt M{\"u}ller and Margareta M{\"u}ller and Irene E. Vignon-Clementel and Dirk Drasdo},
  journal={PLoS computational biology},
  year={2016},
  volume={12 2},
  pages={e1004412}
}
We develop a quantitative single cell-based mathematical model for multi-cellular tumor spheroids (MCTS) of SK-MES-1 cells, a non-small cell lung cancer (NSCLC) cell line, growing under various nutrient conditions: we confront the simulations performed with this model with data on the growth kinetics and spatial labeling patterns for cell proliferation… CONTINUE READING