Inferring Genetic Networks and Identifying Compound Mode of Action via Expression Profiling

  title={Inferring Genetic Networks and Identifying Compound Mode of Action via Expression Profiling},
  author={T. S. Gardner and D. di Bernardo and David Lorenz and J. Collins},
  pages={102 - 105}
  • T. S. Gardner, D. di Bernardo, +1 author J. Collins
  • Published 2003
  • Biology, Medicine
  • Science
  • The complexity of cellular gene, protein, and metabolite networks can hinder attempts to elucidate their structure and function. To address this problem, we used systematic transcriptional perturbations to construct a first-order model of regulatory interactions in a nine-gene subnetwork of the SOS pathway in Escherichia coli. The model correctly identified the major regulatory genes and the transcriptional targets of mitomycin C activity in the subnetwork. This approach, which is… CONTINUE READING
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