Inferring DNA sequences from mechanical unzipping data: the large-bandwidth case.

  title={Inferring DNA sequences from mechanical unzipping data: the large-bandwidth case.},
  author={Valentina Baldazzi and S. Bradde and Simona Cocco and Enzo Marinari and R{\'e}mi Monasson},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  volume={75 1 Pt 1},
The complementary strands of DNA molecules can be separated when stretched apart by a force; the unzipping signal is correlated to the base content of the sequence but is affected by thermal and instrumental noise. We consider here the ideal case where opening events are known to a very good time resolution (very large bandwidth), and study how the sequence can be reconstructed from the unzipping data. Our approach relies on the use of statistical Bayesian inference and of Viterbi decoding… CONTINUE READING

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