Inferring Allele Frequency Trajectories from Ancient DNA Indicates That Selection on a Chicken Gene Coincided with Changes in Medieval Husbandry Practices

@inproceedings{Loog2017InferringAF,
  title={Inferring Allele Frequency Trajectories from Ancient DNA Indicates That Selection on a Chicken Gene Coincided with Changes in Medieval Husbandry Practices},
  author={Liisa Loog and Mark G. Thomas and Ross Barnett and Richard Allen and Naomi Sykes and Ptolemaios D. Paxinos and Ophelie Lebrasseur and Keith M Dobney and Joris Peters and Andrea Manica and Greger Larson and Anders Eriksson},
  booktitle={Molecular biology and evolution},
  year={2017}
}
Ancient DNA provides an opportunity to infer the drivers of natural selection by linking allele frequency changes to temporal shifts in environment or cultural practices. However, analyses have often been hampered by uneven sampling and uncertainties in sample dating, as well as being confounded by demographic processes. Here, we present a Bayesian statistical framework for quantifying the timing and strength of selection using ancient DNA that explicitly addresses these challenges. We applied… CONTINUE READING

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